"Genes, ras" - Books

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See ras resistance to audiogenic seizures in the Gene database

ras in Mus musculus Drosophila melanogaster Aplysia californica All 43 Gene records

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Select item 14152801.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 16686902.

Holland-Frei Cancer Medicine. 6th edition.

Kufe DW, Pollock RE, Weichselbaum RR, et al., editors.

Hamilton (ON): BC Decker; 2003.

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Select item 18602423.

WormBook: The Online Review of C. elegans Biology [Internet].

Pasadena (CA): WormBook; 2005-2018.

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Select item 14589844.

GeneReviews® [Internet].

Adam MP, Feldman J, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2024.

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Select item 44036685.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

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Select item 28215246.

PDQ Cancer Information Summaries [Internet].

Bethesda (MD): National Cancer Institute (US); 2002-.

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Select item 34012947.

Endotext [Internet].

Feingold KR, Anawalt B, Blackman MR, et al., editors.

South Dartmouth (MA): MDText.com, Inc.; 2000-.

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Select item 28206228.

Medical Genetics Summaries [Internet].

Pratt VM, Scott SA, Pirmohamed M, et al., editors.

Bethesda (MD): National Center for Biotechnology Information (US); 2012-.

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Select item 23639749.

Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.

Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.

Cambridge: Cambridge University Press; 2007.

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Select item 159952410.

The Cell: A Molecular Approach. 2nd edition.

Cooper GM.

Sunderland (MA): Sinauer Associates; 2000.

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Select item 189578811.

Molecular Biology of the Cell. 4th edition.

Alberts B, Johnson A, Lewis J, et al.

New York: Garland Science; 2002.

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Select item 265918212.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Select item 544913413.

15th Report on Carcinogens [Internet].

National Toxicology Program.

Research Triangle Park (NC): National Toxicology Program; 2021 Dec 21.

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Select item 186695414.

C. elegans II. 2nd edition.

Riddle DL, Blumenthal T, Meyer BJ, et al., editors.

Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.

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Select item 168684015.

Retroviruses.

Coffin JM, Hughes SH, Varmus HE, editors.

Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.

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Select item 235805216.

Probe Reports from the NIH Molecular Libraries Program [Internet].

Bethesda (MD): National Center for Biotechnology Information (US); 2010-.

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Select item 519713217.

Tumour Site Concordance and Mechanisms of Carcinogenesis.

Baan RA, Stewart BW, Straif K, editors.

Lyon (FR): International Agency for Research on Cancer; 2019. (IARC Scientific Publications, No. 165.)

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Select item 408425418.

Pharmaceuticals.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 2012. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 100A.)

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Select item 408460619.

Chemical Agents and Related Occupations.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 2012. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 100F.)

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Select item 219516220.

StemBook [Internet].

Cambridge (MA): Harvard Stem Cell Institute; 2008-.

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Supplemental Content

Images search in Bookshelf

FIGURE 8-4

Frequency distribution of haplotypes in the RAS genes in whites and blacks.

Genetic Factors in Ethnic Disparities in Health.

National Research Council (US) Panel on Race, Ethnicity, and Health in Later Life; Anderson NB, Bulatao RA, Cohen B, editors. Critical Perspectives on Racial and Ethnic Differences in Health in Late Life. Washington (DC): National Academies Press (US); 2004.
Figure 15.26Oncogenes and signal transduction

Oncogene proteins act as growth factors (e.g., EGF), growth factor receptors (e.g., ErbB), and intracellular signaling molecules (Ras and Raf). Ras and Raf activate the ERK MAP kinase pathway (see Figures 13.32 and 13.35), leading to the induction of additional genes (e.g., fos) that encode potentially oncogenic transcriptional regulatory proteins. Proteins with known oncogenic potential are highlighted with a yellow glow.

Oncogenes.

Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000.
Figure 67-10

PKR and HSV-1. Activation of PKR by double-stranded RNA results in cessation of viral protein synthesis (gray arrows). The HSV-1 viral genes U_S11 or γ134.5 inhibit the action of PKR (black arrows). Activating mutations in Ras can also inhibit activation of the PKR pathway upon viral infection and thereby allow tumor-selective HSV-1 to replicate.

Viral Oncolysis.

Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003.
Figure 6.14

The widely used RTK signal transduction pathway. The receptor tyrosine kinase is dimerized by the ligand, which causes the autophosphorylation of the receptor. The adaptor protein recognizes the phosphorylated tyrosines on the RTK and activates an intermediate protein, GNRP, which activates the Ras G protein by allowing the phosphorylation of the GDP-bound Ras. At the same time, the GAP protein stimulates the hydrolysis of this phosphate bond, returning Ras to its inactive state. The active Ras activates protein kinase C (PKC), which in turn phosphorylates a series of kinases. Eventually, the activated ERK kinase alters gene expression in the responding cell by phosphorylating certain transcription factors (which can then enter the nucleus to change the types of genes transcribed) and certain translation factors (which alter the level of protein synthesis). In many cases, this pathway is reinforced by the release of calcium ions. A simplified version of the pathway is depicted on the left.

Cell Surface Receptors and Their Signal Transduction Pathways.

Gilbert SF. Developmental Biology. 6th edition. Sunderland (MA): Sinauer Associates; 2000.